Glioblastoma Linked to Lyme Disease

Glioblastoma, the most aggressive brain tumor, began to disappear when patients started treatment for chronic Lyme disease. That was my hypothesis ten years ago: the etiology of glioblastoma may begin with a suppressed immune system and hypoxia (low tissue oxygen) created by Borrelia burgdorferi, co-infections, along with a history of head trauma and metal, chemical and/or emotional toxicity. And glioblastoma may resolve upon treating chronic lyme disease and its associated conditions.

In 2006, I began working with my first glioblastoma patient, who to my surprise, I diagnosed with chronic Lyme disease and multiple chronic infections of the brain. Despite surgical resection of the brain tumor, radiation and chemotherapy, the tumor continued to grow until the onset of a holistic treatment approach for chronic Lyme disease began. Within one year, the tumor disappeared and the patient was tumor free for seven years until he was reinfected by a tick bite, instigating the return of the tumor one month after the tick bite. This was clear clinical evidence that chronic infections involving Borrelia burgdorferi may play a large role in the etiology of glioblastoma. I needed further clinical evidence to solidify my hypothesis.

Several patients with glioblastoma have since been diagnosed with Lyme disease at Holistique Naturopathic Medical Center. The most recent patient is Dayna who at the age of 28 was diagnosed with an inoperable glioblastoma multiforme tumor. She began treatment of low dose chemotherapy with her oncologist, refused radiation therapy, and chose to pursue alternative and adjunctive therapies here at Holistique. Again, we diagnosed her with Lyme disease and a non-antibiotic treatment plan was created to address the infection and its co-infections, immunosuppression and associated toxicities and conditions. Again, the tumor shrank and was no longer detectable on PET scan within eleven months later.

Image of a brain scan showing a significant reduction in tumor size thanks to holistic medicine Dayna’s MRI show significant tumor reduction.

Because of the clinical results demonstrated by tumor shrinkage resulting from Lyme disease treatment in every one of my glioblastoma patients, I was convinced that one of the major players in glioblastoma etiology was Borrelia burgdorferi. I now wanted pathological evidence. In October 2015, I met Dr. Alan MacDonald, a retired neuropathologist. Curious to know whether my clinical evidence matched pathological evidence, Dr. MacDonald agreed to analyze pathology slides of glioblastoma biopsies of five patients. What he found was astonishing! He proved my hypothesis and clinical evidence of ten years; he found the DNA of Borrelia burgdorferi inside the cells of glioblastoma tumors, using Flourescent in Situ Hybridization (FISH), in every one of the biopsy slides.

My conclusion: Those patients fighting Glioblastoma multiforme (GBM) must be evaluated and treated for Lyme disease and multiple co-infections. Non-antibiotic based chronic Lyme disease treatment along with low dose chemotherapy may bring hope for these patients.

On April 16th, 2016, I presented my clinical findings for successful treatment of Glioblastoma through the diagnosis and treatment of chronic Lyme disease and its associated conditions at the 14th Annual International Integrative Oncology Conference in San Diego.

Read the update on Dayna’s journey of living with chronic Lyme disease and glioblastoma.

Written by: Dr. Nooshin K. Darvish, N.D., FICT.

24 Comments

  • Amanda

    Your approach to medicine is what the world needs. Not one shoe fits all or strictly pharma OR holistic. The answers are somewhere between. Thank you for your work. I have Lyme and not had a suspicious CT scan. I hope I never have to meet you, but you would definitely be my first choice with help if it proves to be more than encephalopathy. Keep searching for answers!

  • Terra Forsyth

    Is lymes a possible cause of other types of brain tumours?

    • Nooshin K Darvish, ND, FICT, ABAAHP

      Hi Terra. I have not seen research on other tumors related to borreliosis but from my experience in clinical practice, I am finding a very strong association with several different types of brain tumors.

    • Baron

      It’s Lyme not Lymes. And the answer is yes!

    • Nooshin K Darvish, ND, FICT, ABAAHP

      Possibly. Usually there are multiple infections and toxins involved as well as past history of trauma and concussion.

  • Maxime Sauve

    Hello..i have 13 yrs son whith glioblastome multiforme gr 4 whith metastas…dr said no issue …no treatment and c ant accept this ! I want another try..anything ? Do you think is possible whith you ? Sorry for my english !

  • Charlene

    Hi Nooshin,

    I have had Lyme disease and was on antibiotics within the month of receiving bite. Very blessed with no side effects 11 years later. However, had blood work down lately and showed Lyme again no symptoms. Dr put on antibiotic. Could it show up again without a bite?

    • Nooshin K Darvish, ND, FICT, ABAAHP

      Hi Charlene. With antibiotic therapy, Lyme can get suppressed but not resolved, and later, when opportunity arises, the infection can come back. This might be your situation. You may also have been reinfected by mosquitoes and other bug bites, sexual partners,and not know it. For these reasons, I treat the immune system as well as other toxins often involved without antibiotic therapy and using European Biological medicine and proven treatments from around the world. It is also important to check and treat the partner.

  • Marion

    Where in Washington is your clinic and how can we make an appointment? My husband has GBM 4 and I want him tested for Lyme.

  • Maria Kar

    My son has an Oligocene to gloom a type II
    His had surgery chemo and radiation. Never tested for Lyme disease. Any hopes of help ?

    • Nooshin K Darvish, ND, FICT, ABAAHP

      Hello Maria.
      I’m assuming that you mean oligoastrocytoma. I’m so sorry to hear about the condition of your son. He should be tested for Lyme either through #Igenex laboratories or a new #PCR urine test that is now available through #DNAConnexions. DNA Connecions is not completely FDA approved yet but gives great info. Please contact my office for further consult. Warmly, DrD

  • Ashley Rodriguez

    Hi Nooshin, my name is Ashley! I have a brother who is 30 yrs old and suffering everyday. He’s been in the hospital for 2 months now and doctors are giving up on him. He was diagnosed with Lyme but it’s a very confusing situation. I believe it’s also glioblastoma. I don’t want to lose my brother but he needs treatment fast. Please if there is anyways you can help my family.

    • Nooshin K Darvish, ND, FICT, ABAAHP

      Hi Ashley. I’m so sorry to hear about your brother. Please contact my office to set up either a time for a phone or in person consult to see what we can do to help him. My office number is 425-451-0404. Loving Regards,
      DrD

  • Donna

    What about people who have GBM 4 and do not have Lyme disease! My husband never had Lyme disease yet he developed GBM.

    • Nooshin K Darvish, ND, FICT, ABAAHP

      Hi Donna. Testing for lyme disease, especially when there are neurological symptoms, is very inaccurate and majority of cases are missed. He should be tested again using Igenex lab or DNA Connexions or please have the brain biopsy sent to one a neuropathologist who knows how to test for lyme in the sample. Chances are high that he does have tick-borne infection that has been missed on laboratory test. Warm Regards,
      DrD

  • Carisa stone

    I have a glomus vagale tumor. I also tested w two out of the three indications for Lyme on the Western blot test, but was told it is negative. I am heavily symptomatic for Lyme on the daily despite trying supplements daily when I can handle it. I eat very clean and am following a strict diet. Any information would help! Thanks!

    • Nooshin K Darvish, ND, FICT, ABAAHP

      Hi Carisa. I’m sorry to hear of your diagnosis. To give you more accurate suggestions, please contact my office to set up a phone or video consult. 425-451-0404. Look forward to connecting with you.

  • herewegokids7

    My father died from glioblastoma multiform. I have chronic Lyme. I found this article somehow searching pyroluria

    • Nooshin K Darvish, ND, FICT, ABAAHP

      It can all be related. Let us know if you would help treating your chronic Lyme and to evaluate you for pyroluria and other related conditions. All the best to you.

  • Marlene

    I tested positive in 2016 for Lyme disease & in 2017 was diagnosed with Glioblastoma

    • Nooshin K Darvish, ND, FICT, ABAAHP

      I’m sorry to hear that. I will be happy to consult with you to see how I can help you. Please call my office to set up a time. 425-451-0404 or info@HolistiqueHealth.com

      Look forward to connecting soon.

  • Baron

    I totally agree with this! I’m a 30 year Lyme fighter and recently diagnose with a GBM. Docs don’t want to listen to me about this or Dr MacDonalds findings.

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