Glioblastoma Linked to Lyme Disease

Image of a brain scan showing a tumor from Glioblastoma

Glioblastoma Linked to Lyme Disease

Glioblastoma, the most aggressive brain tumor, began to disappear when patients started treatment for chronic Lyme disease. That was my hypothesis ten years ago: the etiology of glioblastoma may begin with a suppressed immune system and hypoxia (low tissue oxygen) created by Borrelia burgdorferi, co-infections, along with a history of head trauma and metal, chemical and/or emotional toxicity. And glioblastoma may resolve upon treating chronic lyme disease and its associated conditions.

In 2006, I began working with my first glioblastoma patient, who to my surprise, I diagnosed with chronic Lyme disease and multiple chronic infections of the brain. Despite surgical resection of the brain tumor, radiation and chemotherapy, the tumor continued to grow until the onset of a holistic treatment approach for chronic Lyme disease began. Within one year, the tumor disappeared and the patient was tumor free for seven years until he was reinfected by a tick bite, instigating the return of the tumor one month after the tick bite. This was clear clinical evidence that chronic infections involving Borrelia burgdorferi may play a large role in the etiology of glioblastoma. I needed further clinical evidence to solidify my hypothesis.

Several patients with glioblastoma have since been diagnosed with Lyme disease at Holistique Naturopathic Medical Center. The most recent patient is Dayna who at the age of 28 was diagnosed with an inoperable glioblastoma multiforme tumor. She began treatment of low dose chemotherapy with her oncologist, refused radiation therapy, and chose to pursue alternative and adjunctive therapies here at Holistique. Again, we diagnosed her with Lyme disease and a non-antibiotic treatment plan was created to address the infection and its co-infections, immunosuppression and associated toxicities and conditions. Again, the tumor shrank and was no longer detectable on PET scan within eleven months later.

Image of a brain scan showing a significant reduction in tumor size thanks to holistic medicine Dayna’s MRI show significant tumor reduction.

Because of the clinical results demonstrated by tumor shrinkage resulting from Lyme disease treatment in every one of my glioblastoma patients, I was convinced that one of the major players in glioblastoma etiology was Borrelia burgdorferi. I now wanted pathological evidence. In October 2015, I met Dr. Alan MacDonald, a retired neuropathologist. Curious to know whether my clinical evidence matched pathological evidence, Dr. MacDonald agreed to analyze pathology slides of glioblastoma biopsies of five patients. What he found was astonishing! He proved my hypothesis and clinical evidence of ten years; he found the DNA of Borrelia burgdorferi inside the cells of glioblastoma tumors, using Flourescent in Situ Hybridization (FISH), in every one of the biopsy slides.

My conclusion: Those patients fighting Glioblastoma multiforme (GBM) must be evaluated and treated for Lyme disease and multiple co-infections. Non-antibiotic based chronic Lyme disease treatment along with low dose chemotherapy may bring hope for these patients.

On April 16th, 2016, I presented my clinical findings for successful treatment of Glioblastoma through the diagnosis and treatment of chronic Lyme disease and its associated conditions at the 14th Annual International Integrative Oncology Conference in San Diego.

Read the update on Dayna’s journey of living with chronic Lyme disease and glioblastoma.

Written by: Dr. Nooshin K. Darvish, N.D., FICT.


Dr. Nooshin K. Darvish is a Washington board-licensed Naturopathic Doctor, certified in Anti-Aging and Regenerative Medicine with a Fellowship in Integrative Cancer Therapies. She is the founder and Chief Medical Officer of Holistique Naturopathic Medical Center and Holistique IV Lounge. A 1995 graduate, former Chief Resident, and an Affiliate Faculty of Bastyr University, with more than 25 years of clinical practice, Dr. Darvish practices Regenerative, Naturopathic, and Integrative medicine with a passion to assist patients in their transformation towards physical, mental, emotional, and spiritual wellness. As a physician, writer, educator, lecturer, and speaker, her mission is to inspire others to become 'agents of transformation'.


  1. Avatar Amanda on February 11, 2018 at 1:49 pm

    Your approach to medicine is what the world needs. Not one shoe fits all or strictly pharma OR holistic. The answers are somewhere between. Thank you for your work. I have Lyme and not had a suspicious CT scan. I hope I never have to meet you, but you would definitely be my first choice with help if it proves to be more than encephalopathy. Keep searching for answers!

  2. Avatar Terra Forsyth on February 12, 2018 at 6:25 am

    Is lymes a possible cause of other types of brain tumours?

  3. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on February 12, 2018 at 9:35 am

    Hi Terra. I have not seen research on other tumors related to borreliosis but from my experience in clinical practice, I am finding a very strong association with several different types of brain tumors.

  4. Avatar Maxime Sauve on February 19, 2018 at 8:28 pm

    Hello..i have 13 yrs son whith glioblastome multiforme gr 4 whith metastas…dr said no issue …no treatment and c ant accept this ! I want another try..anything ? Do you think is possible whith you ? Sorry for my english !

  5. Avatar Charlene on February 22, 2018 at 6:55 am

    Hi Nooshin,

    I have had Lyme disease and was on antibiotics within the month of receiving bite. Very blessed with no side effects 11 years later. However, had blood work down lately and showed Lyme again no symptoms. Dr put on antibiotic. Could it show up again without a bite?

  6. Avatar Marion on February 23, 2018 at 10:21 am

    Where in Washington is your clinic and how can we make an appointment? My husband has GBM 4 and I want him tested for Lyme.

  7. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on February 23, 2018 at 11:33 am

    Hello Marion. Our clinic is in Bellevue, Washington. Please go to our clinic website for more info

  8. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on February 23, 2018 at 11:42 am

    Hi Charlene. With antibiotic therapy, Lyme can get suppressed but not resolved, and later, when opportunity arises, the infection can come back. This might be your situation. You may also have been reinfected by mosquitoes and other bug bites, sexual partners,and not know it. For these reasons, I treat the immune system as well as other toxins often involved without antibiotic therapy and using European Biological medicine and proven treatments from around the world. It is also important to check and treat the partner.

  9. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on February 23, 2018 at 11:44 am

    Hi Maxine please contact my office to set up a time to consult you regarding your son. Our office number is 425-451-0404 or or go to for more info.

  10. Avatar Maria Kar on February 28, 2018 at 6:05 pm

    My son has an Oligocene to gloom a type II
    His had surgery chemo and radiation. Never tested for Lyme disease. Any hopes of help ?

  11. Avatar Ashley Rodriguez on March 1, 2018 at 4:39 pm

    Hi Nooshin, my name is Ashley! I have a brother who is 30 yrs old and suffering everyday. He’s been in the hospital for 2 months now and doctors are giving up on him. He was diagnosed with Lyme but it’s a very confusing situation. I believe it’s also glioblastoma. I don’t want to lose my brother but he needs treatment fast. Please if there is anyways you can help my family.

  12. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on March 2, 2018 at 6:55 am

    Hi Ashley. I’m so sorry to hear about your brother. Please contact my office to set up either a time for a phone or in person consult to see what we can do to help him. My office number is 425-451-0404. Loving Regards,

  13. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on March 2, 2018 at 7:03 am

    Hello Maria.
    I’m assuming that you mean oligoastrocytoma. I’m so sorry to hear about the condition of your son. He should be tested for Lyme either through #Igenex laboratories or a new #PCR urine test that is now available through #DNAConnexions. DNA Connecions is not completely FDA approved yet but gives great info. Please contact my office for further consult. Warmly, DrD

  14. Avatar Donna on March 2, 2018 at 2:16 pm

    What about people who have GBM 4 and do not have Lyme disease! My husband never had Lyme disease yet he developed GBM.

  15. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on March 10, 2018 at 6:51 pm

    Hi Donna. Testing for lyme disease, especially when there are neurological symptoms, is very inaccurate and majority of cases are missed. He should be tested again using Igenex lab or DNA Connexions or please have the brain biopsy sent to one a neuropathologist who knows how to test for lyme in the sample. Chances are high that he does have tick-borne infection that has been missed on laboratory test. Warm Regards,

  16. Avatar Baron on April 29, 2019 at 7:42 pm

    It’s Lyme not Lymes. And the answer is yes!

  17. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on April 29, 2019 at 8:27 pm

    Possibly. Usually there are multiple infections and toxins involved as well as past history of trauma and concussion.

  18. Avatar Carisa stone on May 3, 2019 at 3:15 pm

    I have a glomus vagale tumor. I also tested w two out of the three indications for Lyme on the Western blot test, but was told it is negative. I am heavily symptomatic for Lyme on the daily despite trying supplements daily when I can handle it. I eat very clean and am following a strict diet. Any information would help! Thanks!

  19. Avatar herewegokids7 on May 3, 2019 at 8:12 pm

    My father died from glioblastoma multiform. I have chronic Lyme. I found this article somehow searching pyroluria

  20. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on May 3, 2019 at 9:05 pm

    Hi Carisa. I’m sorry to hear of your diagnosis. To give you more accurate suggestions, please contact my office to set up a phone or video consult. 425-451-0404. Look forward to connecting with you.

  21. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on May 3, 2019 at 9:35 pm

    It can all be related. Let us know if you would help treating your chronic Lyme and to evaluate you for pyroluria and other related conditions. All the best to you.

  22. Avatar Marlene on May 4, 2019 at 8:21 am

    I tested positive in 2016 for Lyme disease & in 2017 was diagnosed with Glioblastoma

  23. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on May 4, 2019 at 10:32 am

    I’m sorry to hear that. I will be happy to consult with you to see how I can help you. Please call my office to set up a time. 425-451-0404 or

    Look forward to connecting soon.

  24. Avatar Luz Campos on May 4, 2019 at 1:46 pm

    Hi my daughter 27 yrs old was diagnosed with glioblastoma almost 2 yrs ago but not sure if she has ever been tested for Lyme disease..Is this something that you highly recommend to get done? How would we go about getting her oncologist to do this testing or who should we ask?

  25. Avatar Jenni stoltman on May 5, 2019 at 3:01 am

    I have ordered but not read , “Don’t kill my Lyme? ” by Wyatt Palumbo? And if so do you agree with this author?

  26. Avatar Lisa on June 26, 2019 at 7:08 pm

    Have you found any connection with high grade midline gliomas? Our son was just diagnosed with DIPG at age 20. He is positive for Babesia and Bartonella Duncan I and elizabethi. He has no symptoms common to Lyme. His sister does have 6 Lyme coinfections. Treatment ideas during chemo and radiation?

  27. Avatar Baron on September 22, 2019 at 6:36 am

    I totally agree with this! I’m a 30 year Lyme fighter and recently diagnose with a GBM. Docs don’t want to listen to me about this or Dr MacDonalds findings.

  28. Nooshin K Darvish, ND, FICT, ABAAHP Nooshin K Darvish, ND, FICT, ABAAHP on January 2, 2020 at 8:22 pm

    I am sorry to hear that Baron. Please contact my office if you would like a consult. 425-451-0404. Sending you healing prayers.