The Longevity Benefits of Curcumin and EGCG

“To the true lover reunion is life…” – The Hidden Words

Latest research on polyphenols delves into the synergistic benefits of Curcumin, the extract from the spice turmeric, and EGCG (epigallocatechin gallate) derived from green tea. The combination of the two appears to have multiple longevity and health optimization benefits – more potent than either one alone.

Anti-allergy and Mast Cell Mitigation:

When curcumin is combined with EGCG, a more potent anti-allergy response is observed than with either one alone. The combo stabilizes mast cells inhibiting their degranulation. Hence, the common histamine response found in allergies, hormonal imbalance, infections and in mast cell syndrome attenuates when using EGCG and Curcumin together. EGCG and Curcumin act synergistically to significantly reduce generalized inflammation.

Cancer:

The combination of Curcumin and EGCG appear to suppress breast cancer stem cells. Prostate cancer cell replication also appears to be inhibited by the combination better than either alone. Cancer resistance was mitigated with the use of the combination, including bladder cancer resistance.

Anti-aging and Memory:

Age associated cellular damage seems to be diminished when Curcumin and EGCG used together reduce inflammation and oxidative stress. The benefits were seen especially in vascular inflammation, and in age-related conditions such as Alzheimer’s and cancer. Age-related memory improvements in mice were observed when EGCG and Curcumin were introduced together.

Hyperlipidemia:

In a 2023 study, Pandit et al found that when curcumin was added to green tea extract, its antihyperlipidemic activity was significantly enhanced. Curcumin seems to improve the absorption and permeability of green tea extract in the intestines.

Conclusion:

The combination of green tea extract ( EGCG) and curcumin from turmeric appear to have several potent health benefits in slowing aging, and promoting longevity by acting as anti-inflammatory and anti- allergy, by retarding age-related conditions while improving brain health, and by inhibiting cancer stem cells thus providing a strong adjunctive cancer therapy option.

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References:

Chung SS, Vadgama JV. Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. Anticancer Res. 2015 Jan;35(1):39-46. PMID: 25550533; PMCID: PMC4290892.

Eom DW, Lee JH, Kim YJ, Hwang GS, Kim SN, Kwak JH, Cheon GJ, Kim KH, Jang HJ, Ham J, Kang KS, Yamabe N. Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. BMB Rep. 2015 Aug;48(8):461-6. doi: 10.5483/bmbrep.2015.48.8.216. PMID: 25441423; PMCID: PMC4576954.

Pandit AP, Joshi SR, Dalal PS, Patole VC. Curcumin as a permeability enhancer enhanced the antihyperlipidemic activity of dietary green tea extract. BMC Complement Altern Med. 2019 Jun 13;19(1):129. doi: 10.1186/s12906-019-2545-1. PMID: 31196040; PMCID: PMC6567481.

Piwowarczyk L, Stawny M, Mlynarczyk DT, Muszalska-Kolos I, Goslinski T, Jelińska A. Role of Curcumin and (-)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review. Cancers (Basel). 2020 Jul 5;12(7):1801. doi: 10.3390/cancers12071801. PMID: 32635637; PMCID: PMC7408736.

Rahman MA, Shuvo AA, Apu MMH, Bhakta MR, Islam F, Rahman MA, Islam MR, Reza HM. Combination of epigallocatechin 3 gallate and curcumin improves D-galactose and normal-aging associated memory impairment in mice. Sci Rep. 2023 Aug 4;13(1):12681. doi: 10.1038/s41598-023-39919-4. PMID: 37542120; PMCID: PMC10403524.

Ruzicka J, Urdzikova LM, Svobodova B, Amin AG, Karova K, Dubisova J, Zaviskova K, Kubinova S, Schmidt M, Jhanwar-Uniyal M, Jendelova P. Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury? Neural Regen Res. 2018 Jan;13(1):119-127. doi: 10.4103/1673-5374.224379. PMID: 29451216; PMCID: PMC5840977.

Queen BL, Tollefsbol TO. Polyphenols and aging. Curr Aging Sci. 2010 Feb;3(1):34-42. doi: 10.2174/1874609811003010034. PMID: 20298168; PMCID: PMC2896035.

Zeng J, Hao J, Yang Z, Ma C, Gao L, Chen Y, Li G, Li J. Anti-Allergic Effect of Dietary Polyphenols Curcumin and Epigallocatechin Gallate via Anti-Degranulation in IgE/Antigen-Stimulated Mast Cell Model: A Lipidomics Perspective. Metabolites. 2023 May 5;13(5):628. doi: 10.3390/metabo13050628. PMID: 37233669; PMCID: PMC10223132.